His literary works are usually within the action genre and heavily feature technology. His novels epitomize the techno-thriller genre of literature, often exploring technology and failures of human interaction with it, especially resulting in catastrophes with biotechnology. Many of his novels have medical or scientific underpinnings, reflecting his medical training and scientific background. He wrote, among other works, The Andromeda Strain (1969); The Great Train Robbery (1975); Congo (1980); Sphere (1987); Jurassic Park (1990); Rising Sun (1992); Disclosure (1994); The Lost World (1995); Airframe (1996); Timeline (1999); Prey (2002); State of Fear (2004); and Next (2006). Films he wrote and directed included Westworld (1973), Coma (1978), The Great Train Robbery (1979), Looker (1981), and Runaway (1984).
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