Born in New Orleans, Rice spent much of her early life there before moving to Texas, and later to San Francisco. She was raised in an observant Catholic family, but became an agnostic as a young adult. She began her professional writing career with the publication of Interview with the Vampire in 1976, while living in California, and began writing sequels to the novel in the 1980s. In the mid-2000s, following a publicized return to Catholicism, Rice published the novels Christ the Lord: Out of Egypt and Christ the Lord: The Road to Cana, fictionalized accounts of certain incidents in the life of Jesus. Several years later she distanced herself from organized Christianity, citing disagreement with the Church's stances on social issues but pledging that faith in God remained "central to [her] life. " However, she now considers herself a secular humanist.
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